Primary drivers

• Retatrutide – multi-agonist (GLP-1 / GIP / glucagon); strongest metabolic & fat-loss signal in your list
   
• Tirzepatide – GLP-1 / GIP; appetite control, insulin sensitivity
   
• Cagrilintide – amylin analog; satiety, appetite suppression
   

Supportive metabolic peptides

• MOTS-c – mitochondrial glucose utilization, metabolic flexibility
   
• 5-Amino-1MQ – NNMT inhibition → energy expenditure (experimental)
   
• SS-31 – mitochondrial efficiency & oxidative stress reduction
   

Optional adjuncts

• MT-2 – appetite suppression + energy (high side-effect awareness)
   
• NAD+ – cellular energy support (not fat loss alone, but synergistic)
   

Conceptual role of this stack:
Appetite control → insulin sensitivity → mitochondrial efficiency → energy expenditure

Primary anabolic / recovery drivers

• Human Growth Hormone (HGH) – direct GH signaling
   
• CJC-1295 (no DAC) – endogenous GH pulse support
   

Tissue repair & injury resilience

• BPC-157 – muscle, tendon, ligament repair
   
• TB-500 (Thymosin Beta-4) – cellular migration & tissue healing
   

Mitochondrial & endurance support

• MOTS-c
   
• SS-31
   

Sleep / recovery quality (indirect muscle growth)

• DSIP – sleep depth & recovery signalling
   

Conceptual role:
GH axis + tissue repair + mitochondrial output + recovery quality

Cellular & mitochondrial longevity

• Epithalon – telomere / circadian regulation
   
• SS-31 – mitochondrial membrane protection
   
• MOTS-c – metabolic longevity signalling
   
• NAD+ – cellular redox & repair
   

Neuroprotection / stress resilience

• Semax – BDNF, neuroplasticity
   
• Selank – anxiolytic, neuroimmune balance
   

Immune aging

• Thymosin Alpha-1 – immune modulation, thymic signalling
   

Conceptual role:
Mitochondria + DNA integrity + brain resilience + immune competence

Reproductive axis & libido

• Kisspeptin – GnRH → LH/FSH signaling (core reproductive peptide)
   
• PT-141 – libido & sexual arousal (central mechanism)
   
• Oxytocin – bonding, sexual satisfaction, stress reduction
   

Mood / anxiety support

• Selank
   
• Semax
   

Skin & connective tissue changes

• GHK-Cu
   
• BPC-157
   

Conceptual role:
Neuroendocrine signalling + sexual function + mood + tissue integrity

Libido & sexual function

• PT-141 – primary libido peptide
   
• Kisspeptin – upstream reproductive hormone signalling
   
• Oxytocin – bonding, sexual response
   

Hormonal support (indirect)

• CJC-1295 (no DAC)
   
• HGH
   

Energy & vitality

• MOTS-c
   
• NAD+
   

Conceptual role:
Central libido signalling + hormonal axis support + cellular energy

Primary skin peptides

• GHK-Cu – collagen synthesis, wound repair, skin thickness
   
• SNAP-8 – expression line reduction (topical)
   
• KPV – anti-inflammatory, barrier repair
   

Systemic repair

• BPC-157
   
• TB-500
   

Pigmentation / tanning

• MT-2 – melanocortin activation (with caution)
   

Conceptual role:
Collagen + inflammation control + cellular repair + pigmentation modulation